Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway
نویسندگان
چکیده
منابع مشابه
Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway
Influenza A virus (IAV) enters host cells upon binding of its hemagglutinin glycoprotein to sialylated host cell receptors. Whereas dynamin-dependent, clathrin-mediated endocytosis (CME) is generally considered as the IAV infection pathway, some observations suggest the occurrence of an as yet uncharacterized alternative entry route. By manipulating entry parameters we established experimental ...
متن کاملMacropinocytosis: an endocytic pathway for internalising large gulps.
Macropinocytosis is a regulated form of endocytosis that mediates the non-selective uptake of solute molecules, nutrients and antigens. It is an actin-dependent process initiated from surface membrane ruffles that give rise to large endocytic vacuoles called macropinosomes. Macropinocytosis is important in a range of physiological processes; it is highly active in macrophages and dendritic cell...
متن کاملSemliki forest virus entry and the endocytic pathway.
Membrane-containing (enveloped) animal viruses introduce their genomes into host cells by membrane fusion. The reaction is catalysed by specific fusogenic spike glycoproteins on the surface of the virions and for many enveloped viruses, including toga-, rhabdoand orthomyxoviruses, mildly acidic conditions (pH 6.2 and below) are required to trigger the fusion activity. In the normal course of en...
متن کاملInfectious entry by amphotropic as well as ecotropic murine leukemia viruses occurs through an endocytic pathway.
Infectious entry of enveloped viruses is thought to proceed by one of two mechanisms. pH-dependent viruses enter the cells by receptor-mediated endocytosis and are inhibited by transient treatment with agents that prevent acidification of vesicles in the endocytic pathway, while pH-independent viruses are not inhibited by such agents and are thought to enter the cell by direct fusion with the p...
متن کاملFilamentous influenza virus enters cells via macropinocytosis.
Influenza virus is pleiomorphic, producing both spherical (100-nm-diameter) and filamentous (100-nm by 20-μm) virions. While the spherical virions are known to enter host cells through exploitation of clathrin-mediated endocytosis, the entry pathway for filamentous virions has not been determined, though the existence of an alternative, non-clathrin-, non-caveolin-mediated entry pathway for inf...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2011
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1001329